De Keyzer started his career as a freelance photographer in 1982 while supporting himself as a photography instructor at the Royal Academy of Fine Arts in Ghent, Belgium. At the same time, his interest in the work of other photographers led him to co-found and co-direct the XYZ-Photography Gallery. A Magnum nominee in 1990, he became a full member in 1994.
De Keyzer likes to tackle large-scale projects and general themes. A basic premise in much of his work is that, in overpopulated communities everywhere, disaster has already struck and infrastructures are on the verge of collapse. His style is not dependent on isolated images; instead, he prefers an accumulation of images which interact with text.
De Keyzer’s work has been exhibited all over the world and he is the recipient of numerous awards, including the Book Award from Rencontres d’Arles, the W. Eugene Smith Award, the Kodak Award and the PDN Book Award for ‘Zona’ – New York 2004.